Whole-cell tumor vaccine based on principle of extracellular trap and method of making same
AssigneeHainan Medical University
InventorsGuang-Hong TAN, Feng-Ying HUANG, Liming ZHANG, Zhuoxuan LV, Ying-Ying LIN
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Abstract
Disclosed are a whole-cell tumor vaccine based on the principle of extracellular traps and a method of making the same, where a CpG ODN network similar to the extracellular trap in structure is formed on the tumor cell surface. The tumor cells are coated with a histone and CpG ODN to form the CpG ODN-coated tumor cells, which are inactivated to produce the whole-cell tumor vaccine. The vaccine of the invention, after injected to tumor model mice, can induce the occurrence of effective immune response to achieve the effective treatment for tumors.
Claims10
A whole-cell tumor vaccine, comprising:
- DNA, a histone and tumor cells;
- wherein the DNA is CpG oligodeoxynucleotide (ODN);
- the tumor cells are isolated and extracted from any tumor tissues;
- the CpG ODN and the histone are coated on a surface of the tumor cells to form an extracellular trap (ET)-like CpG ODN network to obtain CpG ODN-coated tumor cells;
- and
- the CpG ODN-coated tumor cells are inactivated to produce the whole-cell tumor vaccine.
Dependencies are inferred from the claim text.