Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists
AssigneesThe Board of Trustees of the Leland Stanford Junior University, U.S. Government as represented by the Department of Veterans Affairs
InventorsJian Luo, Anton Wyss-Coray
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Abstract
The present invention provides methods for preventing, attenuating neuronal damage or stimulating neuronal repair prior or following central nervous system injury.
Claims23
A method of treating a human subject following acute central nervous system injury, the method comprising administering a pharmaceutical composition comprising at least one macrophage colony stimulating factor receptor agonist to said human within a predetermined time period following said acute central nervous system injury.
The method of claim 4, wherein said acute central nervous system injury is caused by a traumatic brain injury, cerebral ischemia, cerebral glucose deprivation, cerebral oxidative stress, spinal cord injury or excitotoxic injury.
The method of claim 4, wherein said at least one macrophage colony stimulating factor receptor agonist is macrophage colony stimulating factor.
(canceled)
A method of treating a human subject suffering from a chronic central nervous system injury, the method comprising administering a pharmaceutical composition comprising at least one macrophage colony stimulating factor receptor agonist to said human subject following or during said chronic central nervous system injury.
The method of claim 13, wherein said chronic central nervous system injury is caused by a neurodegenerative disease.
(canceled)
A method of attenuating or preventing neuronal damage in a human subject at risk of chronic central nervous system injury, the method comprising administering a pharmaceutical composition comprising at least one macrophage colony stimulating factor receptor agonist to said human subject prior to said chronic central nervous system injury.
(canceled)
Dependencies are inferred from the claim text.