Methods and compositions for modulating myofibroblast activities

A method of forming a medical device, comprising applying a composition to the medical device, the composition comprising an effective amount of fibromodulin peptide for promoting myofibroblast differentiation and apoptosis in a subject having a disorder associated with myofibroblast activity, wherein the composition is a controlled release formulation that provides controlled release of fibromodulin peptide, and

• wherein the composition further comprises TGF-β1.

A medical device comprising a composition, the composition comprising an effective amount of fibromodulin peptide for promoting myofibroblast differentiation and apoptosis in a subject having a disorder associated with myofibroblast activity,

• wherein the composition is a controlled release formulation that provides controlled release of fibromodulin peptide, and
• wherein the composition further comprises TGF-β1.

A method for treating or ameliorating a disorder associated with increased or decreased myofibroblast activity, comprising:

• modulating the myofibroblast level in a subject in need thereof by modulating fibromodulin level in the subject by increasing fibromodulin level or by decreasing fibromodulin level, or modulating myofibroblast differentiation and myofibroblast apoptosis,
• wherein increasing fibromodulin level comprises applying to the subject an effective amount of fibromodulin peptide for promoting the myofibroblast differentiation and myofibroblast apoptosis thereby increasing the myofibroblast level in the subject where early, but short duration myofibroblast activity is effective for the disorder or inhibiting prolonged myofibroblast activity in the subject where the disorder is associated with prolonged myofibroblast activity.