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US 2020/0345807 A1Published application
Psma-targeting amanitin conjugates
AssigneeHeidelberg Pharma Research GmbH
InventorsFrancesca Gallo, Barbara Korsak, Christoph Mueller, Torsten Hechler, Andreas Pahl, Michael Kulke, Werner Simon, Christian Lutz
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Abstract
The invention relates to a PSMA-targeting conjugate comprising (a) an amatoxin; (b) a small molecule PSMA-targeting moiety; and (c) optionally a linker linking said amatoxin and said small molecule PSMA-targeting moiety. The invention furthermore relates to a pharmaceutical composition comprising such conjugate.
Claims22
A conjugate comprising (a) an amatoxin;
- (b) a PSMA-binding moiety based on 2-[3-(1,3-dicarboxy-propyl)ureido]pentanedioic acid (I) or 6-amino-2-[3-(1,3-dicarboxypropyl)ureido]-hexanoic acid (II);
- and (c) a linker linking amatoxin and the PSMA-binding moiety.
Dependencies are inferred from the claim text.