Novel agents targeting inhibitor of apoptosis proteins

A compound, or a pharmaceutical salt thereof, or a prodrug thereof, having the formula:

• wherein,
• R1 is —CX13, —CHX12, —CH2X, substituted or unsubstituted C1-C4 alkyl;
• L2 is a bond, —NH—, —O—, —S—, —C(O)—, —C(O)NH—, —NHC(O)—, —NHC(O)NH—, —C(O)O—, —OC(O)—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• R2 is independently R7-substituted or unsubstituted aryl, or R7-substituted or unsubstituted heteroaryl;
• or
• R2 is independently hydrogen, halogen, —CX23, —CHX22, —CH2X2, —CN, —OH, —NH2, —COH, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX23, —OCHX22, —OCH2X2, —SO2CH3, —SO2CX23, —SO2CH3, —SO2X2, —SO2CH═CH2, —NHSO2CH═CH2, —OSO2X2, —NHSO2X2, —B(OH)2, —CO-oxiranyl, —CO-aziridinyl, epoxidinyl, oxaziridinyl, aziridinyl, —OCH2C≡CH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• L3 is a bond, —NH—, —O—, —S—, —C(O)—, —C(O)NH—, —NHC(O)—, —NHC(O)NH—, —C(O)O—, —OC(O)—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, substituted or unsubstituted alkylarylene, substituted or unsubstituted alkylheteroarylene;
• Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• R3 is independently halogen, —CX33, —CHX32, —CH2X3, —CN, —OH, —NH2, —COH, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX33, —OCHX32, —OCH2X3, —SO2X3, —SO2CH═CH2, —NHSO2CH═CH2, —OSO2X3, —NHSO2X3, —B(OH)2, —CO-oxiranyl, —CO-aziridinyl, epoxidinyl, oxaziridinyl, aziridinyl, —OCH2C≡CH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• two adjacent R3 substituents may optionally be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R4 is independently hydrogen, halogen, —CX43, —CHX42, —CH2X4, —CN, —OH, —NH2, —COH, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX43, —OCHX42, —OCH2X4, —NHC(NH)NH2, —SO2X4, —SO2CH═CH2, —NHSO2CH═CH2, —OSO2X4, —NHSO2X4, —B(OH)2, —CO-oxiranyl, —CO-aziridinyl, epoxidinyl, oxaziridinyl, aziridinyl, —OCH2C≡CH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is independently hydrogen, halogen, —CX53, —CHX52, —CH2X5, —CN, —OH, —NH2, —COH, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX53, —OCHX52, —OCH2X5, —NHC(NH)NH2, —SO2X5, —SO2CH═CH2, —NHSO2CH═CH2, —OSO2X5, —NHSO2X5, —B(OH)2, —CO-oxiranyl, —CO-aziridinyl, epoxidinyl, oxaziridinyl, aziridinyl, —OCH2C≡CH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• L6 is a bond or unsubstituted methylene;
• R6 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R7 is independently halogen, —CX73, —CHX72, —CH2X7, —CN, —OH, —NH2, —COH, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX73, —OCHX72, —OCH2X7, —NHC (NH)NH2, —N═C(NH2)2, —CH2SO3−, —PO3−2, —SO3−, —SO2NH2, —CH2PO3−2, —CH2SO2NH2, —NHC(O)CHCH2, —NHC(O)CH2Cl, —B(OH)2, —SO2X7, —OSO2X7, —NHSO2X7, —SO2CH═CH2, —NHSO2CH═CH2, —CO-oxiranyl, —CO-aziridinyl, epoxidinyl, oxaziridinyl, aziridinyl, —OCH2C≡CH, R8-substituted or unsubstituted alkyl, R8-substituted or unsubstituted heteroalkyl, R8-substituted or unsubstituted cycloalkyl, R8-substituted or unsubstituted heterocycloalkyl, R8-substituted or unsubstituted aryl, or R8-substituted or unsubstituted heteroaryl;
• R8 is independently halogen, —CX83, —CHX82, —CH2X8, —CN, —OH, —NH2, —COH, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX83, —OCHX82, —OCH2X8, —NHC (NH)NH2, —N═C(NH2)2, —CH2SO3−, —PO3−2, —SO3−, —SO2NH2, —CH2PO3−2, —CH2SO2NH2, —NHC(O)CHCH2, —NHC(O)CH2Cl, —B(OH)2, —SO2X8, —OSO2X8, —NHSO2X8, —SO2CH═CH2, —NHSO2CH═CH2, —CO-oxiranyl, —CO-aziridinyl, epoxidinyl, oxaziridinyl, aziridinyl, —OCH2C≡CH, R9-substituted or unsubstituted alkyl, R9-substituted or unsubstituted heteroalkyl, R9-substituted or unsubstituted cycloalkyl, R9-substituted or unsubstituted heterocycloalkyl, R9-substituted or unsubstituted aryl, or R9-substituted or unsubstituted heteroaryl;
• R9 is independently halogen, —CX93, —CHX92, —CH2X9, —CN, —OH, —NH2, —COH, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX93, —OCHX92, —OCH2X9, —NHC (NH)NH2, —N═C(NH2)2, —CH2SO3−, —PO3−2, —SO3−, —SO2NH2, —CH2PO3−2, —CH2SO2NH2, —NHC(O)CHCH2, —NHC(O)CH2C1, —B(OH)2, —SO2X9, —OSO2X9, —NHSO2X9, —SO2CH═CH2, —NHSO2CH═CH2, —CO-oxiranyl, —CO-aziridinyl, epoxidinyl, oxaziridinyl, aziridinyl, —OCH2C≡CH, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• each X1, X2, X3, X4, X5, X7, X8, and X9 is independently —F, —Cl, —Br, or —I;
• and
• z3 is independently an integer from 0 to 3.