Synergistic Bacterial Compositions and Methods of Production and Use Thereof
AssigneeSeres Therapeutics, Inc.
InventorsMatthew R. Henn, Kevin Daniel Litcofsky, Anthony Mario D'Onofrio, Toshiro K. Ohsumi, Mary-Jane Lombardo McKenzie, Geoffrey von Maltzahn, David N. Cook, David Arthur Berry, Noubar B. Afeyan, John Grant Aunins
Life of this patent
Estimating the term…
Abstract
Provided are therapeutic compositions containing microbial populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
Claims29
A composition comprising at least a first species of an isolated bacterium capable of forming a spore, a second species of isolated bacterium capable of forming a spore, and a third species of isolated bacterium capable of forming a spore, wherein the first species, the second species, and the third species of bacteria are not identical, wherein the first species comprises a 16S rDNA sequence that is at least 97% identical to SEQ ID NO:
- 559, SEQ ID NO:
- 609, or SEQ ID NO:
- 886, and wherein of the first species, the second species, and the optional third species can synergistically decrease and/or inhibit the growth and/or colonization of at least one type of pathogenic bacteria, as measured by a CivSim assay.
2-12. (canceled)
14-18. (canceled)
20-21. (canceled)
23-75. (canceled)
77-97. (canceled)
99-157. (canceled)
159-169. (canceled)
171-224. (canceled)
226-245. (canceled)
A method of producing a bacterial composition, comprising combining at least a first species of isolated bacterium capable of forming a spore, a second species of isolated bacterium capable of forming a spore, and a third species of isolated bacterium capable of forming a spore, wherein the first species, the second species, and the third species are not identical, wherein the first species comprises a 16S rDNA sequence that is at least 97% identical to SEQ ID NO:
- 559, SEQ ID NO:
- 609, or SEQ ID NO:
- 886, and wherein the first species, the second species, and the third species can synergistically decrease and/or inhibit the growth and/or colonization of at least one type of pathogenic bacteria, as measured by a CivSim assay.
Dependencies are inferred from the claim text.