Human hepatocytes and uses thereof
AssigneeAccelerated Biosciences Corp.
InventorsJau-Nan LEE, Tony Tung-Yin LEE, Yuta LEE, Eing-Mei TSAI
Life of this patent
Estimating the term…
Abstract
Disclosed herein are human hepatocytes for example isolated human hepatic progenitor cells, artificial tissue or organ thereof, and kits or compositions thereof. Also disclosed herein are various methods of using a human hepatocyte disclosed herein.
Claims19
1-89. (canceled)
An isolated human hepatocyte, wherein the isolated human hepatocyte endogenously expresses transforming growth factor beta 1 (TGFβ1), fibronectin, and collagen IV.
An artificial tissue or organ, comprising human hepatocytes that express alpha-1-fetoprotein (AFP), albumin (ALB), alpha-1-antitrypsin, glucose, or glycogen.
An artificial tissue or organ, comprising human hepatocytes that endogenously express human leukocyte antigen G (HLA-G) and one or more biomarkers from C—X—C chemokine receptor type 4 (CXCR4), forkhead box protein A2 (FOXA2), hematopoietically expressed homeobox (HHEX), cytochrome P450 7A1 (CYP7A1), bile salt export pump (BSEP), alpha-1-antitrypsin member 1 (SERPINA1), ATP-binding cassette sub-family C member 2 (ABCC2), CCAAT-enhancer-binding protein beta (C/EBPβ), hepatocyte nuclear factor 1-alpha (HNF1α), or any combination thereof.
Dependencies are inferred from the claim text.