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US 2020/0345775 A1Published application
Msc-expressed immunomodulators in combination with car-t for cancer therapy
AssigneeThe Brigham and Women's Hospital, Inc.
InventorKhalid SHAH
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Abstract
This technology describes novel cell based combined therapeutic modalities that induces mechanism based tumor cell killing in a broad spectrum of sensitive and resistant tumors. These new agents are tumor specific and target a broad spectrum of solid tumors.
Claims27
A method of treating a solid tumor cancer in a subject, the method comprising:
- a. administering a genetically modified T cell expressing on its cell surface a chimeric T cell antigen receptor comprising a heterologous binding domain that specifically binds a tumor antigen expressed on the surface of cells of the cancer, and an intracellular signaling domain, wherein binding of the heterologous binding domain to the tumor antigen on the surface of a cancer cell activates the intracellular signaling domain and the T cell;
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- b. administering a first genetically modified mesenchymal stem cell, that expresses a heterologous immunomodulatory polypeptide,
- wherein the heterologous immunomodulatory polypeptide potentiates cancer cell killing by the genetically modified T cell.
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A composition comprising:
- a. a genetically modified T cell expressing on its cell surface a chimeric T cell antigen receptor comprising a heterologous binding domain that specifically binds a tumor antigen expressed on the surface of cells of a cancerous tumor, and an intracellular signaling domain, wherein binding of the heterologous binding domain to the tumor antigen on the surface of a cancer cell activates the intracellular signaling domain and the T cell;
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- b. a first genetically modified mesenchymal stem cell, that expresses a heterologous immunomodulatory polypeptide.
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Dependencies are inferred from the claim text.