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AssigneeRensselaer Polytechnic Institute
InventorsRobert Linhardt, Jing Zhao, Fuming Zhang, Pieter Muntendam
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A therapeutic composition includes a polysaccharide, isolated from a member of the genus Cucurbita, e.g., pumpkin, having a backbone including alternating α-L-rhamnosyl (α-L-Rhap) and α-D-galactopyranosyluronic acid (α-D-GapA) residues, and a side chain attached to the backbone including β-D-galactan (β-D-Galp), α-L-arabinofuranosyl (α-L-Araf), or combinations thereof, and a pharmaceutically acceptable excipient. A β-D-Galp side chain is attached to the backbone at the C-4 carbon of at least one α-L-Rhap of the backbone. At least one α-L-Araf is attached to the β-D-Galp side chain. The α-L-Araf is attached to the β-D-Galp side chain via the C-3 carbon of the β-D-Galp. The polysaccharide is effective for treating a galectin-3 dependent disorder by binding to the carbohydrate recognition domain of galectin-3, resulting in inhibition of galectin-3 activity.
A method of treating a galectin-3 dependent disorder, comprising:
A method of isolating a polysaccharide comprising:
A therapeutic composition comprising:
The therapeutic composition according to claim 18, wherein the polysaccharide has a structure according to the following Formula I:
Dependencies are inferred from the claim text.