Bicyclic sulfonamides

A compound of Formula (I), or a pharmaceutically acceptable salt thereof, having the structure:

• wherein:
• is a single or a double bond,
• wherein when is a single bond, then Z1 is CR8AR9A and Z2 is CR8BR9B;
• and
• wherein when is a double bond, then Z1 and Z2 are each independently CR10;
• R1 is a substituted or an unsubstituted C2-8 alkenyl or a substituted or an unsubstituted C2-8 alkynyl, wherein the substituted C2-8 alkenyl and the substituted C2-8 alkynyl is substituted with one or more substituents independently selected from halogen, hydroxy, an optionally substituted monocyclic C3-6 cycloalkyl, an optionally substituted bicyclic C3-8 cycloalkyl, an optionally substituted monocyclic heterocyclyl and R11A;
• R2 is hydrogen, deuterium or a substituted or an unsubstituted C1-4 alkyl, wherein the substituted C1-4 alkyl is substituted with one or more substituents selected from halogen, hydroxy and R11B;
• R3 is hydrogen, deuterium or an unsubstituted C1-4 alkyl;
• R4 is hydrogen, deuterium or an unsubstituted C1-4 alkyl;
• R5 is hydrogen, deuterium, halogen, an unsubstituted C1-4 alkyl, cyano, an unsubstituted C1-4 haloalkyl or an unsubstituted C3-8 monocyclic cycloalkyl;
• R6 is a substituted phenyl or a substituted pyridyl, wherein the substituted phenyl and the substituted pyridyl is substituted with one or more substituents independently selected from halogen, cyano, an unsubstituted C1-4 haloalkyl and an unsubstituted C1-4 alkyl;
• and
• R7 is hydrogen, deuterium or an unsubstituted C1-4 alkyl;
• R8A, R8B, R9A and R9B are independently hydrogen, deuterium, halogen, an unsubstituted C1-4 alkyl or hydroxy;
• each R10 are independently hydrogen, deuterium, halogen or an unsubstituted C1-4 alkyl;
• and
• R11A and R11B are independently an optionally substituted —O-acyl, an unsubstituted O-linked α-amino acid, —O—P(═O)(OH)2 or —CH2—P(═O)(OH)2.