Solid forms of a toll-like receptor modulator
AssigneeGilead Sciences, Inc.
InventorsSylvie M. Asselin, Pavel R. Badalov, Henry G. Morrison, Christopher S. Regens, Tiago Vieira
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Abstract
The present disclosure provides crystalline forms, solvates and hydrates of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol, and methods of making.
Claims39
A crystalline form of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol (Compound I):
- characterized by an X-ray powder diffraction (XRPD) pattern comprising three or more peaks at 10.9°, 11.5°, 13.2°, 14.7°, 15.5°, 21.4°, 21.9°, 23.2°, or 24.9° 2θ (±0.2° 2θ), Form I.
A crystalline form of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-olhydrochloride:
- characterized by an XRPD pattern comprising three or more peaks at 6.1°, 12.2°, 15.0°, 17.3°, 17.8°, 18.9°, 20.3°, 23.2°, or 24.1° 2θ (±0.2° 2θ), hydrochloride salt Form I.
-25. (canceled)
A crystalline form of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-olhydrochloride:
- characterized by an XRPD pattern comprising three or more peaks at 7.1°, 9.7°, 14.3°, 15.3°, 16.1°, 19.1°, 22.5°, 24.0°, or 26.0° 2θ (±0.2° 2θ), hydrochloride salt Form II.
-37. (canceled)
A crystalline form of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol tartaric acid:
- characterized by an XRPD pattern comprising three or more peaks at 6.3°, 9.9°, 12.5°, 17.7°, 18.3°, 19.2°, 23.4°, 25.7°, or 28.1° 2θ (±0.2° 2θ), Compound I tartaric acid.
-49. (canceled)
A crystalline form of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol maleic acid:
- characterized by an XRPD pattern comprising three or more peaks at 7.3°, 8.4°, 8.8°, 13.9°, 15.6°, 17.7°, 20.7°, 24.7°, or 27.4° 2θ (±0.2° 2θ), Compound I maleic acid.
-61. (canceled)
A crystalline form of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol fumaric acid:
- characterized by an XRPD pattern comprising three or more peaks at 6.7°, 8.3°, 10.1°, 12.6°, 16.1°, 18.5°, 20.6°, 25.2° or 27.6° 2θ (±0.2° 2θ), Compound I fumaric acid.
-74. (canceled)
A crystalline form of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol methanesulfonic acid:
- characterized by an XRPD pattern comprising three or more peaks at 5.4°, 10.4°, 10.8°, 15.8°, 17.3°, 18.1°, 20.5°, 20.8°, or 23.9° 2θ (±0.2° 2θ), Compound I methanesulfonic acid.
-87. (canceled)
An amorphous solid form of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol:
(canceled)
(canceled)
93-99. (canceled)
-121. (canceled)
Dependencies are inferred from the claim text.