Hydroxylated and methoxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors

A method of inhibiting the production of AKT protein kinase in a mammal in need thereof, the method comprising administering to the mammal an effective amount of a compound of Formula (I) a tautomer thereof, a resolved enantiomer thereof, a resolved diastereomer thereof, or a salt thereof;

• wherein the compound of Formula (I) is:
• wherein:
• R1 is H, Me, Et, vinyl, CF3, CHF2 or CH2F;
• R2 is H or Me;
• R5 is H, Me, Et, or CF3;
• A is
• G is phenyl optionally substituted by one to four R9 groups or a 5-6 membered heteroaryl optionally substituted by a halogen;
• R6 and R7 are independently H, OCH3, (C3-C6 cycloalkyl)-(CH2), (C3-C6 cycloalkyl)-(CH2CH2), V—(CH2)0-1 wherein V is a 5-6 membered heteroaryl, W—(CH2)1-2 wherein W is phenyl optionally substituted with F, Cl, Br, I, OMe, CF3 or Me, C3-C6-cycloalkyl optionally substituted with C1-C3 alkyl or O(C1-C3 alkyl), hydroxy-(C3-C6-cycloalkyl), fluoro-(C3-C6-cycloalkyl), CH(CH3)CH(OH)phenyl, 4-6 membered heterocycle optionally substituted with F, OH, C1-C3 alkyl, cyclopropylmethyl or C(═O)(C1-C3 alkyl), or C1-C6-alkyl optionally substituted with one or more groups independently selected from OH, oxo, O(C1-C6-alkyl), CN, F, NH2, NH(C1-C6-alkyl), N(C1-C6-alkyl)2, cyclopropyl, phenyl, imidazolyl, piperidinyl, pyrrolidinyl, morpholinyl, tetrahydrofuranyl, oxetanyl or tetrahydropyranyl,
• or R6 and R7 together with the nitrogen to which they are attached form a 4-7 membered heterocyclic ring optionally substituted with one or more groups independently selected from OH, halogen, oxo, CF3, CH2CF3, CH2CH2OH, O(C1-C3 alkyl), C(═O)CH3, NH2, NHMe, N(Me)2, S(O)2CH3, cyclopropylmethyl and C1-C3 alkyl;
• Ra and Rb are H,
• or Ra is H, and Rb and R6 together with the atoms to which they are attached form a 5-6 membered heterocyclic ring having one or two ring nitrogen atoms;
• Rc and Rd are H or Me,
• or Rc and Rd together with the atom to which they are attached form a cyclopropyl ring;
• R8 is H, Me, F or OH,
• or R8 and R6 together with the atoms to which they are attached form a 5-6 membered heterocyclic ring having one or two ring nitrogen atoms;
• each R9 is independently halogen, C1-C6-alkyl, C3-C6-cycloalkyl, O—(C1-C6-alkyl), CF3, OCF3, S(C1-C6-alkyl), CN, OCH2-phenyl, CH2O-phenyl, NH2, NH—(C1-C6-alkyl), N—(C1-C6-alkyl)2, piperidine, pyrrolidine, CH2F, CHF2, OCH2F, OCHF2, OH, SO2(C1-C6-alkyl), C(O)NH2, C(O)NH(C1-C6-alkyl), and C(O)N(C1-C6-alkyl)2;
• R10 is H or Me;
• and
• m, n and p are independently 0 or 1.