Methods of treating ocular conditions

A method for increasing the amount or concentration of one or more lacrimal proteins produced by an individual in need thereof, comprising local administration of a therapeutically effective amount of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, or a pharmaceutically acceptable salt thereof, in alternating nostrils of an individual in need thereof,

• wherein the therapeutically effective amount per dose is between 1 microgram and 5 milligrams of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, or a pharmaceutically acceptable salt thereof, per dose.