Immunomodulation by IAP Inhibitors
AssigneesNovartis AG, Dana-Farber Cancer Institute, Inc.
InventorsLeigh ZAWEL, Christopher S. STRAUB, Brant G. FIRESTONE, Glenn DRANOFF, Michael DOUGAN
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Abstract
The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.
Claims35
A vaccine comprising an immunogenic quantity of an antigen and an adjuvant comprising an IAP inhibitor.
A method of enhancing an immune response of a subject to an antigen, comprising the steps of:
- (a) administering to the subject an immunogenic quantity of an antigen, wherein the antigen comprises a pathogen, an attenuated pathogen, or a portion thereof;
- and
- (b) administering an immune enhancing amount of an IAP inhibitor.
A method of treating a solid tumor in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of an IAP inhibitor and an immunogenic quantity of an antigen, wherein administration of the IAP inhibitor and the antigen enhances the immune response of the subject to the solid tumor.
A method of treating an infection caused by an infectious agent, comprising administering to a subject in need thereof a therapeutically effective amount of an TAP inhibitor and an immunogenic quantity of an antigen, wherein administration of said TAP inhibitor and said antigen enhances the immune response of the subject to the infectious agent.
A method of treating an autoimmune disorder in a subject, comprising administering to the subject a composition comprising an TAP inhibitor, such that the autoimmune disorder is treated.
A method of enhancing an immune activity of an activated immune cell, comprising contacting an activated immune cell with an TAP inhibitor.
A kit comprising:
- (a) a pharmaceutical composition comprising an IAP inhibitor and a pharmaceutically acceptable carrier;
- (b) a packaging material enclosing said pharmaceutical composition;
- and
- (c) instructions for use of said pharmaceutical composition for the enhancement of an immune response of a subject.
Dependencies are inferred from the claim text.