Combination therapy of axl inhibitor and egfr tyrosine kinase inhibitor
AssigneeDaiichi Sankyo Company, Limited
InventorTakeshi JIMBO
Life of this patent
Estimating the term…
Abstract
The present invention provides a medicament comprising a compound represented by general formula (1) which has Axl inhibitory activity, and an EGFR tyrosine kinase inhibitor in combination, and a method for treating cancer using this combination. The present invention provides an excellent medicament and method for treating cancer which is highly effective for inhibiting resistance to an EGFR tyrosine kinase inhibitor in cancer treatment, and causes less adverse reactions such as weight loss.
Claims18
A medicament comprising a compound of formula (1):
- [N-[4-(2-amino-5-{4-[(2R)-1,4-dioxan-2-ylmethoxy]-3-methoxyphenyl}pyridin-3-yl)-3-fluorophenyl]-5-methyl-4′-oxo-1′-(tetrahydro-2H-pyran-4-ylmethyl)-1′,4′-dihydro-2,3′-bipyridine-5′-carboxamide] or a pharmaceutically acceptable salt thereof and an EGFR tyrosine kinase inhibitor.
A method of treating a cancer, comprising administering a compound of formula (1):
- [N-[4-(2-amino-5-{4-[(2R)-1,4-dioxan-2-ylmethoxy]-3-methoxyphenyl}pyridin-3-yl)-3-fluorophenyl]-5-methyl-4′-oxo-1′-(tetrahydro-2H-pyran-4-ylmethyl)-1′,4′-dihydro-2,3′-bipyridine-5′-carboxamide] or a pharmaceutically acceptable salt thereof and an EGFR tyrosine kinase inhibitor in combination,
- wherein the cancer is selected from breast cancer, colon cancer, colorectal cancer, prostate cancer, lung cancer, gastric cancer, ovary cancer, endometrial cancer, kidney cancer, hepatocellular cancer, thyroid gland cancer, uterus cancer, esophagus cancer, osteosarcoma, skin cancer, glioblastoma, neuroblastoma, head and neck cancer, testicular tumor, blood cancer and pancreatic cancer.
13-15. (canceled)
(canceled)
Dependencies are inferred from the claim text.