Liquid pharmaceutical composition

#The present invention relates to a pharmaceutical liquid composition, and more particularly to a physically and chemically stable pharmaceutical liquid composition including sodium picosulfate, magnesium oxide, citric acid and malic acid.

#A medicine including citric acid magnesium oxide and sodium picosulfate is used as a purgative for pretreatment at the time of surgery, colonoscopy or colon X-ray inspection, and is currently commercially available as the name of Picolight power. This medicine is white powder which is used by being dissolved in water when taken orally.

#The medicine in the dosage form of powder should be taken by dissolving one package in a suitable amount of water. However, some patients may feel inconvenient when dissolving the medicine in water, and some patients who fail to recognize how to use properly may drink water after putting the powder into the mouth. In this case, exothermic reaction occurring when the powder is dissolved in water may burn the patient's mouth.

#FIG. 1 is a process flow diagram illustrating a method of manufacturing a pharmaceutical liquid composition according to an embodiment of the present invention.

#Although the present invention may be variously changed and include several embodiments, particular embodiments shown in the drawings will be described in detail in a detailed description. However, it is to be understood that the present invention is not limited to the particular embodiments, and various changes, equivalences and substitutions may be made without departing from the scope and spirit of the invention.

#A pharmaceutical liquid composition was prepared by dissolving, in purified water in a weight ratio of 75, sodium picosulfate:magnesium oxide:citric acid:dl-malic acid in a weight ratio of 0.005:1.75:6:4.19, sodium benzoate in a weight ratio of 0.043 as a preservative, disodium edetate hydrate in a weight ratio of 0.035 as a stabilizer, sodium hydroxide in a weight ratio of 2.1 as a pH adjuster, acesulfame potassium in a weight ratio of 0.1, and sucralose in a weight ratio of 0.1 as a sweetener, and a fragrance ingredient in orange flavor in a weight ratio of 0.043.

#A powder composition was prepared by including sodium picosulfate:magnesium oxide:citric acid in a weight ratio of 0.005:1.75:6, sodium hydrogen carbonate in a weight ratio of 0.21 as an excipient, acesulfame potassium qs (quantum satis) as a sweetener, and a fragrance ingredient having orange flavor qs (quantum satis).