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US 2020/0345704 A1Published application
Compounds and compositions for treating hematological disorders
AssigneeCuris, Inc.
InventorRobert Booher
Life of this patent
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Abstract
The present invention provides methods of treating hematological disorders and solid malignant tumors, using substituted indazole compounds and pharmaceutically acceptable salts thereof. The compounds inhibit IRAK4 and BCL-2 kinases.
Claims30
1-116. (canceled)
A method of treating Diffuse Large B-cell Lymphoma (DLBCL) in a subject, comprising administering to the subject compound A and venetoclax, wherein compound A is
- and the subject has a mutation in the TLR/IL-1R signaling pathway or the BCR signaling pathway.
Dependencies are inferred from the claim text.