Therapeutic targeting of receptor tyrosine kinase inhibitor-induced androgen receptor phosphoryation in cancer
AssigneeIndiana University Research and Technology Corporation
InventorRoberto Pili
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Abstract
Disclosed herein are compositions and methods for treating cancer. More particularly, the present disclosure relates to compositions and methods for treating cancer including prostate cancer, renal cell carcinoma, hepatocellular carcinoma, thyroid cancer, sarcoma breast cancer, and gastrointestinal stromal tumor. The present disclosure also relates to methods for identifying subjects having drug resistant prostate cancer and drug resistant renal cell carcinoma.
Claims53
A composition comprising an androgen receptor antagonist and a kinase inhibitor.
A method of treating a subject having or suspected of having renal cell carcinoma, the method comprising:
- administering to the subject a composition comprising an androgen receptor antagonist.
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A method of identifying a subject having or suspected of having drug resistant renal cell carcinoma, the method comprising:
- obtaining a sample from the subject;
- and detecting androgen receptor expression, detecting androgen receptor phosphorylation, and combinations thereof.
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A method of treating a subject having or suspected of having cancer, the method comprising:
- administering to the subject a composition comprising an androgen receptor antagonist.
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A method of identifying a subject having or suspected of having drug resistant prostate cancer, the method comprising:
- obtaining a sample from the subject;
- and detecting androgen receptor expression, detecting androgen receptor phosphorylation, and combinations thereof.
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A method of treating a subject having or suspected of having a solid tumor, the method comprising:
- administering to the subject a composition comprising an androgen receptor antagonist and a kinase inhibitor.
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Use of a composition comprising an androgen receptor antagonist and a kinase inhibitor to treat cancer.
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Dependencies are inferred from the claim text.