Compositions comprising indigo and/or an indigo derivative and methods of use thereof
AssigneeAzora Therapeutics, Inc.
InventorsJulie Patricia Saiki, Matthew Davidson, Johan Oscar Lennart Andreasson, Michael David Favero, Matthew Benjamin Greene
Life of this patent
Estimating the term…
Abstract
Compositions comprising an AhR agonist compound, such as indigo and/or an indigo derivative, such as indirubin and isatin, are described. Methods of treatment, including the treatment of ulcerative colitis, by administering the compositions are described. In an embodiment, compositions in the form of a solid amorphous dispersion of the AhR agonist are described.
Claims20
A dosage form, comprising:
- a solid dispersion of an aryl hydrocarbon receptor agonist and a polymeric hydrophilic carrier, wherein aryl hydrocarbon receptor agonist is in a substantially amorphous form in the dispersion.
A formulation, comprising:
- a solid dispersion comprising amorphous synthetic indirubin in a hydrophilic polymer carrier, wherein the indirubin is in a substantially amorphous form in the dispersion;
- and
- one or more excipients in an amount greater than about 20 wt % of the formulation and blended with the solid dispersion to form a blend.
Indirubin or a pharmaceutically acceptable salt thereof wherein the indirubin has a 14C content of less than 0.9 ppt.
Dependencies are inferred from the claim text.