METHODS AND COMPOSITIONS UTILIZING RRx-001 COMBINATION THERAPY FOR RADIOPROTECTION
AssigneeEpicentRx, Inc.
InventorsBryan T. ORONSKY, Amold ORONSKY, Tony R. REID
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Abstract
Provided herein are therapeutic methods, kits, and pharmaceutical compositions for protecting a subject from radiation using a therapeutic agent selected from the group consisting of RRx-OO1 and a pharmaceutically acceptable salt thereof. One exemplary therapeutic method involves administering RRx-OO1 to the subject prior to the subject being exposed to the radiation, in order to protect the subject against radiation, such as ionizing radiation containing α-rays, β-rays, γ-rays, neutron radiation, or a combination thereof.
Claims80
A method for treating a subject in need of protection against radiation, comprising administering to the subject in need thereof (i) an effective amount of a first therapeutic agent selected from the group consisting of RRx-001 and a pharmaceutically acceptable salt thereof and (ii) an effective amount of a second therapeutic agent that reduces the effect of radiation on a subject, to thereby protect the subject against radiation.
A method of reducing radiation-exposure damage to a subject, comprising administering to the subject in need thereof (i) an effective amount of a first therapeutic agent selected from the group consisting of RRx-001 and a pharmaceutically acceptable salt thereof and (ii) an effective amount of a second therapeutic agent that reduces the effect of radiation on a subject, to thereby reduce radiation-exposure damage to the subject.
A method of protecting biological material from the damaging effects of radiation, comprising exposing said biological material to i) an effective amount of a first therapeutic agent selected from the group consisting of RRx-001 and a pharmaceutically acceptable salt thereof and (ii) an effective amount of a second therapeutic agent that reduces the effect of radiation on a subject, to thereby protect the biological material from the damaging effects of radiation.
Dependencies are inferred from the claim text.