Methods and compositions for treating chemotherapy-induced diarrhea
AssigneeNapo Pharmaceuticals, Inc.
InventorLisa A. Conte
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Abstract
Presented herein are methods for treating diarrhea by administering to a patient in need thereof, an inhibitor of chloride-ion transport in an amount sufficient to treat diarrhea. Treatment of diarrhea includes the treatment of the diarrhea as well as the pain, abdominal discomfort and other symptoms associated with diarrhea. In one embodiment, the inhibitor of chloride-ion transport is crofelemer.
Claims23
A method of treating chemotherapy-induced diarrhea (CID) in a human subject undergoing chemotherapy comprising administering to a subject in need thereof a composition comprising an effective amount of crofelemer to treat CID, wherein the chemotherapeutic is a tyrosine kinase inhibitor.
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A method of treating CID in a human subject undergoing chemotherapy for HER positive breast cancer, said method comprising administering to said human subject a composition comprising an crofelemer at a dose of 125 mg twice per day, wherein the chemotherapy is neratinib, with or without carboplatin.
Dependencies are inferred from the claim text.