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US 2020/0345680 A1Published application
Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep
AssigneesCurrax Pharmaceuticals LLC, ProCom One, Inc.
InventorsRoberta L. Rogowski, Susan E. Dubé, Philip Jochelson, Neil B. Kavey
Life of this patent
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Abstract
Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
Claims10
A method for treating sleep maintenance insomnia characterized by fragmented sleep during the 8th hour of sleep in a patient in need thereof, comprising:
- identifying an elderly patient having a sleep disorder in which, for a given 8 hour period of desired sleep, the patient experiences fragmented sleep during the final 60 minutes of said period;
- and
- administering to the patient, prior to the start of the sleep period, doxepin or a pharmaceutically acceptable salt thereof in dosage that is effective to improve sleep maintenance insomnia by reducing fragmented sleep during the 8th hour of the sleep period, wherein the dosage is at least 3 mg, up to 6 mg.
A method for treating sleep maintenance insomnia characterized by early awakenings during the 8th hour of sleep in a patient in need thereof, comprising:
- identifying an elderly patient having a sleep disorder in which, for a given 8 hour period of desired sleep, the patient experiences early awakenings during the final 60 minutes of said period;
- and
- reducing early awakenings during the 8th hour of the sleep period by administering to the patient, prior to the sleep period, a dosage of doxepin or the pharmaceutically acceptable salt thereof that is effective to improve sleep maintenance insomnia by reducing early awakenings during the 8th hour of the sleep period, wherein the dosage is least 3 mg, up to 6 mg.
Dependencies are inferred from the claim text.