Treatment of nervous system disorders using combinations of rxr agonists and thyroid hormones
AssigneeIo Therapeutics, Inc.
InventorsRoshantha A. Chandraratna, Martin E. Sanders
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Abstract
Disclosed herein are methods of treating disease with a combination of a RXR agonist and a thyroid hormone.
Claims20
A method of growing neurons or glial cells in vitro comprising culturing the cells in the presence of a RXR agonist, a thyroid hormone, and a neurotrophic factor or neurotrophic factor mimetic, wherein the RXR agonist is a compound having the structure of formula II:
- wherein R is H or lower alkyl of 1 to 6 carbons, or a pharmaceutically acceptable salt thereof.
A method of treating a nervous system disorder, the method comprising administering to a human individual in need thereof a therapeutically effective amount of neurons or glial cells cultured in vitro according to the method of 1.
A method of treating a nervous system disorder, the method comprising administering to a human individual in need thereof a therapeutically effective amount of a RXR agonist and a thyroid hormone, wherein administration of the combination of the RXR agonist and the thyroid hormone treats the disorder in the individual, wherein the RXR agonist is a compound having the structure of formula II:
- wherein R is H or lower alkyl of 1 to 6 carbons, or a pharmaceutically acceptable salt thereof;
- wherein the combination of RXR agonist and thyroid hormone causes a greater improvement in the disorder than the RXR agonist or thyroid hormone alone.
Dependencies are inferred from the claim text.