Methods of treatment using sustained release sotalol formulations
AssigneeThe Roshni Singh 2015 Trust
InventorBramah N. Singh
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Abstract
Sustained release compositions of sotalol, or a pharmaceutically acceptable salt thereof, are provided. In certain examples, sotalol, or a pharmaceutically acceptable salt thereof, may be administered in an effective amount to provide a therapeutic effect to a patient, such as, for example, a patient suffering from a cardiac disorder. In some examples, sotalol combined with a sustained release system may be administered to provide a sustained release of sotalol for a desired period, e.g., at least about 24 hours.
Claims15
-12. (canceled)
A sustained release composition comprising:
- an effective amount of a racemic mixture of D-sotalol and L-sotalol, or a pharmaceutically acceptable salt thereof;
- and
- a sustained release system, whereby the sustained release system is effective to provide sustained release of the racemic mixture of D-sotalol and L-sotalol or the pharmaceutically acceptable salt thereof for at least about 24 hours when exposed to an environmental fluid.
A sustained release composition comprising:
- an effective amount of a racemic mixture of D-sotalol and L-sotalol, or a pharmaceutically acceptable salt thereof;
- a sustained release excipient system comprising at least one of a heteropolysaccharide gum and a homopolysaccharide gum that is capable of cross-linking;
- and
- a pharmaceutically acceptable cationic cross-linking agent capable of cross-linking with the gums and increasing the gel-strength of the gums when exposed to an environmental fluid or environment of use,
- whereby the sustained release composition is effective to provide sustained release of the racemic mixture of D-sotalol and L-sotalol or the pharmaceutically acceptable salt thereof for at least about 24 hours when exposed to the environmental fluid or the environment of use.
A sustained release composition comprising:
- an effective amount of a racemic mixture of D-sotalol and L-sotalol, or a pharmaceutically acceptable salt thereof;
- and
- a sustained release system, whereby the sustained release system is effective to provide sustained release of the racemic mixture of D-sotalol and L-sotalol or the pharmaceutically acceptable salt thereof,
- wherein the sustained release system is at least one of a topical, rectal, oral and parental system.
Dependencies are inferred from the claim text.