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AssigneeDuke University
InventorsBlanche Capel, Jennifer McKey, Tetsuhiro Yokonishi
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The present disclosure relates to compositions and methods for ablating epithelial cells, in particular to methods for ablating Sertoli cells in testis, and methods related thereto. In particular, the present disclosure relates to methods for ablating Sertoli and other cells in the testis using benzalkonium chloride, to methods for rescuing endogenous spermatogenesis in a subject suffering from Sertoli cell dysfunction, to methods of reconstructing spermatogenesis, to methods of treating infertility, and to methods for the selective depletion of epithelial cells in a tissue and for the treatment of diseases or disorders associated with damaged epithelial cells.
A method for ablating Sertoli cells in a subject comprising administering to the subject an effective amount of a solution of benzalkonium chloride (BC).
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A method for rescuing endogenous spermatogenesis in a subject suffering from Sertoli cell dysfunction comprising:
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A method of reconstructing spermatogenesis of a subject comprising:
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A method of reconstructing spermatogenesis of a subject comprising:
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A method for selectively depleting epithelial cells in a tissue in a subject, comprising administering to the subject an effective amount of BC.
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Dependencies are inferred from the claim text.