Muscular atrophy-inducing agent using hypometabolism-inducing substance t1am, and use thereof in treating muscular hypertrophy

Abstract

A screening method for a drug for treating muscular atrophy is proposed. The method may include the steps of: (a) inducing muscular atrophy by administering to a normal cell or a normal animal a hypometabolism-inducing substance selected from the group consisting of 3-iodothyronamine (T1AM), [D-Ala2, D-Leu5] enkephalin (DADLE), 5′-adenosine monophosphate (5′-AMP), and hydrogen sulfide (H2S); (b) treating a candidate substance in the cell or animal treated with the hypometabolism-inducing substance; (c) evaluating the degree of improvement or treatment of muscular atrophy in the cell or animal treated with the candidate substance; and (d) determining the candidate substance as a drug for treating muscular atrophy.

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