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US 2020/0345661 A1Published application
Small molecule cmklr1 antagonists in inflammatory disease
AssigneesThe Board of Trustees of the Leland Stanford Junior University, The United States Government as represented by the Department of Veterans Affairs
InventorsSanjay Malhotra, Vineet Kumar, Melissa LaJevic, Mallesh Pandrala, Brian A. Zabel
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Abstract
α-NETA analogs are provided for the treatment of inflammatory disease.
Claims11
A method of decreasing inflammatory disease in a subject, the method comprising:
- administering to said subject an effective amount of a compound of formula (I):
- (I), wherein
- Q is selected from —NRQ4+,—NH4+, —NH2, —NHRQ, —NRQ2, —OH, —SH, and lower alkyl;
- wherein RQ is lower alkyl;
- and wherein;
- Q is selected from —NRQ4+ or —NH4+, then X— is present and is a counterion;
- R1 and R2 are independently selected from hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, amino, substituted amino, carboxyl, carboxyl ester, cyano, halogen, acyl, aminoacyl, nitro, and sulfonyl;
- and
- n is a number from one to four.
6 more elements
A compound of formula I formula (I):
- wherein
- Q is selected from —NRQ4+,—NH4+, —NH2, —NHRQ,—NRQ2, —OH, —SH, and lower alkyl;
- wherein RQ is lower alkyl;
- and wherein;
- Q is selected from —NRQ4+ or —NH4+, then X− is present and is a counterion;
- R1 and R2 are independently selected from hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, amino, substituted amino, carboxyl, carboxyl ester, cyano, halogen, acyl, aminoacyl, nitro, and sulfonyl;
- and
- n is a number from one to four.
5 more elements
Dependencies are inferred from the claim text.