Compositions Of Dimethyl Trisulfide (DMTS) As A Cyanide Antidote

A method of treating cyanide intoxication in a subject comprising administering to a subject who would benefit from such treatment an organic-solvent free composition comprising:

• dimethyl trisulfide at 10 wt. % to 20 wt. %;
• sodium chloride at 0.1 wt. % to 10 wt. %;
• one or more surfactants present at a level of 22 wt. % to 45 wt. %;
• the balance water wherein said composition optionally includes an organic solvent at a level of up to and including 5000 ppm and wherein said dimethyl trisulfide composition, when stored at a temperature of 20° C. to 25° C. in a sealed ampoule provides that at least 90% or more by weight of the dimethyl trisulfide remains available for therapeutic use for a period of up to and including twenty-six moths.

An autoinjector comprising an injection volume of 0.15 ml to 5.00 ml, said autoinjector configured to deliver a dose of a composition upon activation by an individual, the composition comprising,

• dimethyl trisulfide at a level of 10 wt. % to 20 wt. %;
• sodium chloride at 0.1 wt. % to 10 wt. %;
• one or more surfactants present at a level of 22 wt. % to 45 wt. %;
• the balance water, wherein the volume of the composition is in the range of 0.15 ml to 5.00 ml and an organic solvent is optionally present at a level of up to and including 5000 ppm;
• wherein said dimethyl trisulfide composition, when stored at a temperature of 20° C. to 25° C. in a said autoinjector provides that at least 90% or more by weight of the dimethyl trisulfide remains available for therapeutic use.

A composition comprising a mixture of:

• dimethyl trisulfide at a level of 15 wt. % to 50 wt. %;
• one or more surfactants at a level of 20 wt. % to 65 wt. %;
• an organic co-solvent present at 10 wt. % to 55 wt. %;
• water present at a level of 10 wt. % to 55 wt. %.

A method of treating cyanide intoxication in a subject comprising:

• administering to a subject who would benefit from such treatment a composition comprising:
• dimethyl trisulfide present at a level of 15 wt. % to 50 wt. %;
• one or more surfactants present at a level of 20 wt. % to 65 wt. %;
• an organic co-solvent present at a level of 10 wt. % to 55 wt. %;
• and
• water present at a level of 10 wt. % to 55 wt. %.

An autoinjector comprising:

• an injection volume of 0.15 ml to 5.00 ml, said autoinjector configured to deliver a dose of a composition upon activation by an individual, the composition comprising:
• dimethyl trisulfide present at a level of 15 wt. % to 50 wt. %;
• one or more surfactants present at a level of 20 wt. % to 65 wt. %;
• an organic co-solvent present at a level of 10 wt. % to 55 wt. %;
• water present at a level of 10 wt. % to 55 wt. %;
• and
• wherein the volume of the composition is in the range of 0.15 ml to 5.00 ml.

A method of treating cyanide intoxication in a subject comprising:

• administering to a subject who would benefit from such treatment a water free composition comprising:
• dimethyl trisulfide present at a level of 15 wt. % to 50 wt. %;
• one or more surfactants present at a level of 20 wt. % to 75 wt. %;
• an organic solvent present at a level of 10 wt. % to 65 wt. % and wherein said composition optionally contains water at a level of up to 5000 ppm.

An autoinjector comprising:

• an injection volume of 0.15 ml to 5.00 ml, said autoinjector configured to deliver a dose of a water free composition upon activation by an individual, the composition comprising:
• dimethyl trisulfide present at a level of 15 wt. % to 50 wt. %;
• surfactant present at a level of 20 wt. % to 75 wt. %;
• an organic solvent present at a level of 10 wt % to 65 wt. %;
• wherein the volume of the composition is in the range of 0.15 ml to 5.00 ml and wherein said composition optionally contains water at a level of up to 5000 ppm.