Treatment of opioid use disorder, opioid withdrawal symptoms, and chronic pain
AssigneeThe Regents of the University of California
InventorsKeith G. HEINZERLING, Marisa S. BRIONES, Dustin Z. DEYOUNG
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Abstract
The current methods and compositions provide for a novel and effective therapeutic method for treating opioid use disorder, opioid withdrawal symptoms and/or chronic pain. Accordingly, certain aspects of the disclosure relate to a method for treating opioid use disorder, opioid withdrawal symptoms and/or chronic pain in a subject, the method comprising administering at least one purified cannabinoid compound and a partial opioid agonist. In some embodiments, the method comprises administering a composition comprising cannabidiol and buprenorphine.
Claims71
A method of treating opioid use disorder, opioid withdrawal symptoms, and/or chronic pain in a subject comprising administering to the subject at least one purified cannabinoid compound and a partial opioid agonist.
A pharmaceutical composition comprising a cannabinoid and a partial opioid agonist.
A pharmaceutical composition comprising 2-900 mg cannabidiol and 0.005-50 mg buprenorphine.
A pharmaceutical composition comprising 2-900 mg cannabidiol, 0.005-50 mg buprenorphine, and 0.01-12.5 mg naloxone.
A method of treating opioid use disorder, opioid withdrawal symptoms, and/or chronic pain in a subject comprising administering to the subject the pharmaceutical composition comprising a purified cannabinoid and a partial opioid agonist in a ratio of 10:1, 20:1, 30:1, 40:1, 50:1, 60:1, 70:1, 80:1, 90:1, 100:1, 200:1, 500:1, 1000:1, 1100:1, 1200:1, 1300:1, 1400:1, 1500:1, 1600:1, 1700:1, 2000:1, 3000:1, 4000:1, 5,000:1, 10,000:1, 15,000:1, or 18,000:1.
A pharmaceutical composition comprising a purified cannabinoid and a partial opioid agonist in a ratio of 10:1, 20:1, 30:1, 40:1, 50:1, 60:1, 70:1, 80:1, 90:1, 100:1, 200:1, 500:1, 1000:1, 1100:1, 1200:1, 1300:1, 1400:1, 1500:1, 1600:1, 1700:1, 2000:1, 3000:1, 4000:1, 5,000:1, 10,000:1, 15,000:1, or 18,000:1.
Dependencies are inferred from the claim text.