Surface-modified mesoporous silica nanoparticle for blood-brain barrier penetration,tumor targeting and cancer metastasis treatment, methods of production and uses thereof
AssigneeNano Targeting & Therapy Biopharma Inc.
InventorsCheng-Hsun WU, Yi-Ping CHEN, Si-Han WU, Chung-Yuan MOU
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Abstract
The present disclosure relates to mesoporous silica nanoparticles (MSNs) with specific modifications as drug delivery systems containing both tumor targeting and blood-brain barrier (BBB) penetration properties suitable for cancer treatment and/or CNS disease treatment. The present disclosure also relates to method of preparing MSNs and the MSNs prepared by the method as described herein.
Claims20
A mesoporous silica nanoparticle, comprising an organic modification on a surface thereof, having a zeta potential within the range from about −22 mV to about +25 mV at pH 7.4 and a particle size of about 50 nm or less, wherein the organic modification comprises a poly(ethylene glycol) (PEG) moiety and at least one of positively charged group containing oligomer/polymer, wherein the positively charged group containing oligomer/polymer is hidden within the PEG moiety, wherein the molar ratio of the poly(ethylene glycol) moiety to the positively charged group containing oligomer/polymer lies within the range from 15:1 to 1:2.
A method for preparing a mesoporous silica nanoparticle (MSN) with surface modification, comprising the steps of:
- (a) providing an alkaline solution containing a surfactant at a concentration sufficient for forming micelles;
- (b) introducing silane source(s) into the solution;
- (c) introducing surface modifying agents comprising at least one PEG-modified silane and at least one positively charged group containing silane into the solution;
- the mole ratio of PEG-modified silane to positively charged group containing silane lies within a range from 15:1 to 1:2
- (d) conducting hydrothermal treatment to the solution;
- (e) collecting the products;
- (f) removing the residual surfactant(s) from the products;
- and optionally
- (g) purifying or cleaning the products.
A method of inhibiting cellular metastasis in a subject comprising administering a mesoporous silica nanoparticle to the subject through systemic or local administration.
Dependencies are inferred from the claim text.