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US 2020/0345642 A1Published application
Method for treating neoplasms using hollow silica spheres
AssigneeImam Abdulrahman Bin Faisal University
InventorsAyhan BOZKURT, Seyda Tugba Gunday ANIL, Firdos Alam KHAN, Sultan AKHTAR
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Abstract
The invention pertains to a method for treating a neoplasm, such as colorectal cancer, using hollow silica spheres (“HSS”). It also is directed to a method for making uncalcined HSS, calcined HSS from which phenyl groups have been removed, and HSS incorporating particles of Fe3O4, as well as compositions containing HSS
Claims20
A method for treating a subject having a neoplasm, comprising:
- administering to the subject a composition comprising Fe3O4-hollow silica spheres (“Fe—HSS”),
- wherein the subject is in need of treatment for the neoplasm.
A sterile composition, comprising:
- hollow silica spheres that incorporate Fe3O4 (“Fe—HSS”) that have not been sintered and a pharmaceutically acceptable excipient or carrier.
A method for forming hollow silica spheres incorporating Fe3O4 (“Fe—HSS”) comprising:
- dissolving a hydrolyzable aryl silane in an aqueous solution comprising Fe3O4, water and an acid to form a hydrolyzed silane solution, wherein a molar ratio of the hydrolysable aryl silane to the Fe3O4 ranges from 100:1 to 1:100;
- mixing the hydrolyzed silane solution with a hydroxide base to form a precipitate;
- and
- recovering Fe—HSS from the precipitate.
1 more element
Dependencies are inferred from the claim text.