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US 2020/0345639 A1Published application
Tailored liposomes for the treatment of bacterial infections
AssigneeUniversitaet Bern
InventorsEduard BABIYCHUK, Annette DRAEGER
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AssigneeUniversitaet Bern
InventorsEduard BABIYCHUK, Annette DRAEGER
Estimating the term…
The invention relates to the use of empty liposomes of defined lipid composition or mixtures of empty liposomes of defined lipid composition and to the use of other lipid bilayers or monolayers of defined lipid composition for the treatment and prevention of bacterial infections. It has been found that such liposomes, in particular a two-and a four-component mixture of liposomes comprising cholesterol and sphingomyelin, liposomes consisting of sphingomyelin, liposomes comprising sphingomyelin and phosphatidylcholine, and liposomes comprising cholesterol and phosphatidylcholine efficiently sequestrate a variety of toxins secreted by bacteria, thus preventing binding of bacterial toxins to target cells and toxin-induced lysis of the target cells. Injected intravenously, liposome mixtures prevented death of laboratory mice infected with lethal doses of Staphylococcus aureus or Streptococcus pneumoniae.
Empty liposomes comprising cholesterol and sphingomyelin, and mixtures of empty liposomes comprising cholesterol and sphingomyelin, or phosphatidylcholine and sphingomyelin, with other empty liposomes of defined lipid composition for use in the treatment and prevention of bacterial infections.
Lipid bilayers or lipid monolayers comprising cholesterol and sphingomyelin, and optionally phosphatidylcholine, covering non-lipid surfaces, for use in the treatment and prevention of bacterial infections.
A mixture of empty liposomes comprising cholesterol and sphingomyelin, or phosphatidylcholine and sphingomyelin, with other empty liposomes of defined lipid composition.
A method of treating bacterial infections comprising administering to a patient in need thereof a therapeutically effective amount of empty liposomes comprising cholesterol and sphingomyelin, or of a mixture of empty liposomes comprising cholesterol and sphingomyelin, or phosphatidylcholine and sphingomyelin, with other empty liposomes of defined lipid composition.
A method of preventing a bacterial infection comprising administering to a subject exposed to the risk of infection a preventive amount of empty liposomes comprising cholesterol and sphingomyelin, or of a mixture of empty liposomes comprising cholesterol and sphingomyelin, or phosphatidylcholine and sphingomyelin, with other empty liposomes of defined lipid composition effective for protection.
A method of treating bacterial infections comprising administering to a patient in need thereof a therapeutically effective amount of empty liposomes comprising cholesterol and sphingomyelin, or of a mixture of empty liposomes comprising cholesterol and sphingomyelin, or phosphatidylcholine and sphingomyelin, with other empty liposomes of defined lipid composition before, after, together or in parallel with a standard antibiotic medication against the bacterial infection.
Dependencies are inferred from the claim text.