Trans-tympanic membrane delivery platform and uses thereof
AssigneeThe Medical College of Wisconsin, Inc.
InventorsAmit Joshi, Joseph Edward Kerschner, Wenzhou Hong, Gayatri Sharma
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Abstract
Provided herein are methods and composition for trans-tympanic membrane delivery of therapeutic agents such as antimicrobial agents, anti-inflammatory agents, and anti-biofilm agents to the middle ear for rapid, localized treatment and prevention of diseases and conditions associated with a middle ear infection. In particular, provided herein are cationic, anionic, and polymer-based nanoparticles that provide a platform for delivery of therapeutic cargo, as well as cationic, anionic, and polymer-based nanoparticles compositions for rapid, localized delivery of therapeutic agents to the middle ear.
Claims20
A method of treating a subject having or suspected of having otitis media associated with a middle ear infection, the method comprising topically applying into the ear canal of an ear of the subject an aqueous suspension composition comprising nanoparticles and a pharmaceutically acceptable aqueous carrier, wherein the nanoparticles comprise a therapeutically effective amount of one or more therapeutic agents;
- whereby, the topically applied nanoparticles diffuse through the ear's tympanic membrane, thereby delivering the one or more therapeutic agents to the middle ear and treating the otitis media.
A pharmaceutical composition for preventing and alleviating otitis media, the composition comprising a therapeutically effect amount of nanoparticles that comprise at least one therapeutic agent in aqueous suspension, the nanoparticles having an average diameter size of about 50 nm to about 150 nm.
A method for trans-tympanic membrane delivery of a therapeutic agent, the method comprising topically applying into the ear canal of an ear of the subject an aqueous suspension composition comprising cationic nanoparticles and a pharmaceutically acceptable aqueous carrier, wherein the cationic nanoparticles comprise a therapeutically effective amount of a therapeutic agent, whereby, the topically applied cationic nanoparticles diffuse through the ear's tympanic membrane, thereby delivering the therapeutic agent to the middle ear.
Dependencies are inferred from the claim text.