Compositions and methods for improving skin appearance
AssigneeAllergan Industrie, SAS
InventorsPierre LEBRETON, Olivier GUETTA
Life of this patent
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Abstract
Injectable compositions and methods of treating skin can help improve hydration, elasticity and/or texture of the skin. The compositions can be based on crosslinked hyaluronic acid matrices made with low molecular weight hyaluronic acids.
Claims14
A method of improving at least one of texture, hydration, or elasticity of skin, the method comprising treating an area of skin by introducing into a skin region, in a single treatment session, multiple, spaced apart injections, of a composition comprising a hyaluronic acid (HA) gel comprising a crosslinked HA matrix made with more than 50% by weight, at least 70% by weight or at least 90% by weight of a low molecular weight HA material having a weight average molecular weight of between 400,000 Da and 800,000 Da, based on a total weight of the HA material;
- wherein a HA concentration of the composition is 10.0 mg/g to 12 mg/g;
- and wherein the crosslinked HA matrix is crosslinked with a crosslinking agent selected from the group consisting of 1,4-butanediol diglycidyl ether (BDDE), 1,2-bis(2,3-epoxypropoxy)ethylene and 1-(2,3-epoxypropyl)-2,3-epoxycyclohexane;
- wherein the injections are spaced apart by a distance of between 5 mm to 20 mm;
- and
- wherein the treated skin maintains at least one of an improved texture, hydration, or elasticity due to the treatment for at least 3 months.
Dependencies are inferred from the claim text.