Preservative removal from eye drops
AssigneeTearclear Corp.
InventorsMichael WILSON, Michael WILLIAMS, Deniz HAY, Michael MALANGA
Life of this patent
Estimating the term…
Abstract
A particulate plug for removing a preservative from a solution, suspension, or emulsion comprising a drug is presented. The plug comprises microparticles of oxidized polyolefin (OxPO). The microparticles are irregular-shaped rigid aggregates and are sized and packed to yield a hydraulic permeability greater than 0.01 Da. The OxPO have absorbed portions of a preservative to be removed and/or a drug for delivery in solution, as can the copolymer.
Claims20
A device for removing a preservative from an ophthalmic formulation, the device comprising:
- a polymeric matrix disposed within an outlet of a reservoir, the reservoir comprising a solution, emulsion, or suspension disposed within the reservoir, wherein the solution, emulsion, or suspension comprises the preservative to be removed and an ophthalmic agent;
- wherein the polymeric matrix is permeable to the solution, emulsion, or suspension, wherein the polymeric matrix comprises microparticles of oxidized polyolefin (OxPO), wherein the polymeric matrix has a partition coefficient for the preservative that is greater than a partition coefficient for the ophthalmic agent, and wherein a time scale for removal of the preservative is shorter than a timescale for flow of the solution, emulsion, or suspension through the polymeric matrix to an exterior of the reservoir.
A method of removing a preservative from a drug solution, suspension, or emulsion, comprising:
- receiving a device comprising:
- a polymeric matrix disposed within an outlet of a reservoir, the reservoir comprising a solution, emulsion, or suspension disposed within the reservoir, wherein the solution, emulsion, or suspension comprises a preservative to be removed and an ophthalmic agent;
- wherein the polymeric matrix comprises microparticles of oxidized polyolefin (OxPO), and wherein the polymeric matrix has a partition coefficient for the preservative that is greater than a partition coefficient for the ophthalmic agent;
- and
- forcing the drug solution, suspension, or emulsion through the device, wherein a time scale for removal of the preservative is shorter than a timescale for flow of the solution, emulsion, or suspension through the polymeric matrix to an exterior of the reservoir.
A method of manufacture of a preservative removing device configured to be disposed within an outlet of a reservoir comprising a solution, emulsion, or suspension, wherein the solution, emulsion, or suspension comprises a preservative to be removed and an ophthalmic agent, the method comprising:
- forming a polymeric matrix, wherein the polymeric matrix comprises microparticles of a polyolefin;
- and
- oxidizing the polyolefin to form an oxidized polyolefin, wherein the polymeric matrix comprising the oxidized polyolefin comprises a partition coefficient for the preservative that is greater than a partition coefficient for the ophthalmic agent, and wherein the polymeric matrix comprising the oxidized polyolefin comprises a time scale for removal of the preservative that is shorter than a timescale for flow of the solution, emulsion, or suspension through the polymeric matrix to an exterior of the reservoir.
Dependencies are inferred from the claim text.