Amnion putty for cartilage repair
OwnerRobert L. Bundyinventor
Life of this patent
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Abstract
There are disclosed compositions for achieving reverse phase characteristics, methods of preparation thereof, and the use of amniotic tissue for cartilage repair. In an embodiment, a biocompatible articular tissue repair composition may have a therapeutic material and a carrier configured for achieving reverse phase characteristics, and methods for using the composition. In various embodiments, the therapeutic material may be amniotic tissue. In various embodiments, the carrier may be a poloxamer such as poloxamer 407. Other embodiments are also disclosed.
Claims20
1-17. (canceled)
A biocompatible articular cartilage tissue repair composition, comprising:
- components of amniotic tissue, and the components of the amniotic tissue including at least one of cut amniotic tissue, blended amniotic tissue, chopped amniotic tissue, and mixed amniotic tissue;
- and
- a reverse phase mixture of poloxamer and amniotic fluid, the reverse phase mixture configured as a carrier of the amniotic tissue, and the carrier configured to resorb after a first period of time at a cartilage defect site while leaving the amniotic tissue at the cartilage defect site to allow ingrowth of the amniotic tissue into the cartilage defect site;
- wherein the composition exhibits reverse phase behavior, wherein the composition is non-liquid at ambient and body temperatures, and wherein the composition supports the amniotic tissue with the carrier at the cartilage defect site for the first period of time for the carrier to resorb.
A method to repair cartilage tissue, the method comprising:
- providing a biocompatible cartilage repair composition, comprising:
- amniotic tissue, the amniotic tissue including at least one of cut amniotic tissue, blended amniotic tissue, chopped amniotic tissue, and mixed amniotic tissue, and
- a reverse phase mixture of poloxamer and a liquid, wherein the composition exhibits reverse phase behavior and is non-liquid at ambient and body temperatures;
- and
- placing the composition in a cartilage defect of a mammal.
A biocompatible articular cartilage tissue repair composition, comprising:
- amniotic tissue, the amniotic tissue including at least one of cut amniotic tissue, blended amniotic tissue, chopped amniotic tissue, and mixed amniotic tissue, and
- a reverse phase mixture of poloxamer and amniotic fluid;
- wherein the composition exhibits reverse phase behavior and is non-liquid at ambient and body temperatures.
Dependencies are inferred from the claim text.