Systems and methods for assessing sympathetic nervous system tone for renal neuromodulation therapy
AssigneeMedtronic Ardian Luxembourg S.a.r.l.
InventorsDouglas HETTRICK, Shantanu SARKAR
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Abstract
Systems and methods for assessing sympathetic nervous system (SNS) tone for renal neuromodulation therapy are disclosed herein. A system configured in accordance with embodiments of the present technology can include, for example, a detector attached to or implanted in a patient and a receiver communicatively coupled to the detector. The detector can measure cardiac data and the receiver and/or a device communicatively coupled thereto can analyze the cardiac data to provide one or more SNS tone indicators. The SNS tone indicators can be used to determine whether a patient will be responsive to a neuromodulation therapy and/or whether a neuromodulation therapy was effective.
Claims20
A method of evaluating effectiveness neuromodulation therapy on a patient, comprising:
- determining, by a processor, a plurality of sympathetic nervous system (SNS) tone indicators based on a plurality of cardiac measurements;
- correcting, by the processor, abnormalities within the plurality of SNS tone indicators;
- determining, by the processor, whether an SNS tone of the patient is elevated based on a comparison between an SNS tone indicator of the plurality of SNS tone indicators and a corresponding threshold;
- and
- determining, by the processor, that neuromodulation therapy is effective on the patient when the SNS tone of the patient is elevated.
A method for assessing effectiveness of neuromodulation therapy on a patient, comprising:
- determining, by a processor, a plurality of pre-therapy sympathetic nervous system (SNS) tone indicators;
- measuring, by the processor, a plurality of cardiac measurements after neuromodulation therapy;
- determining, by the processor, a plurality of post-therapy SNS tone indicators based on the plurality of cardiac measurements;
- determining, by the processor, an amount or degree of change between the plurality of post-therapy SNS tone indicators and the plurality of pre-therapy SNS tone indicators;
- and
- determining that the neuromodulation therapy is successful when the amount or degree of change is at least a desired amount or degree.
A method of evaluating effectiveness of neuromodulation therapy on a patient, comprising:
- determining, by a processor, a plurality of sympathetic nervous system (SNS) tone indicators based on a plurality of cardiac measurements;
- weighting the plurality of SNS tone indicators;
- determining an integrated SNS risk score based on two or more of the plurality of SNS tone indicators and the weighting;
- determining, by the processor, whether the SNS tone of the patient is elevated based on a comparison between the integrated SNS risk score and a corresponding threshold;
- and
- determining, by the processor, that neuromodulation therapy is effective on the patient when the SNS tone of the patient is elevated.
Dependencies are inferred from the claim text.