Method for the diagnosis of airway disease inflammatory subtype
AssigneeUniversite De Liege
InventorFlorence SCHLEICH
Life of this patent
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Abstract
In vitro methods for diagnosing, prognosing and/or monitoring neutrophilic or eosinophilic airway inflammation in a subject, comprising determining the amount of one or more volatile organic compounds (VOCS) in exhaled breath from said subject. The invention also provides devices for use of said methods.
Claims21
1) An in vitro method of diagnosing, prognosing and/or monitoring neutrophilic airway inflammation in a subject, comprising determining the amount of one or more volatile organic compounds (VOCs) selected from the group consisting of:
- 3-tetradecene (C14H28),
- 1-pentadecene (C15H30),
- 3,7-dimethylnonane (C11H24),
- nonanal (C9H18O), and
- 1-propanol (C3H8O),
- in a sample of exhaled breath from said subject.
6) An in vitro method of discriminating neutrophilic airway inflammation from paucigranulocytic airway inflammation in a subject, comprising the steps of:
- a) determining the amount of one or more volatile organic compounds (VOCS) selected from the group consisting of:
- 3-tetradecene (C14H28), and
- 1-pentadecene (C15H30),
- in a sample of exhaled breath from said subject;
- and
- b) comparing said amount of one or more VOCS with a reference value.
9) An in vitro method of discriminating neutrophilic airway inflammation from eosinophilic airway inflammation in a subject, comprising the steps:
- a) determining the amount of one or more volatile organic compounds (VOCS) selected from the group consisting of:
- 3,7-dimethylnonane (C11H24),
- nonanal (C9H18O), and
- 1-propanol (C3H8O),
- in a sample of exhaled breath from said subject;
- and
- b) comparing said amount of one or more VOCS with a reference value.
14) A device for use in an in vitro method of diagnosing, prognosing and/or monitoring neutrophilic airway inflammation, or of discriminating neutrophilic airway inflammation from paucigranulocytic or eosinophilic airway inflammation in a subject, said device comprising detection means for one or more VOCS selected from the group consisting of:
- 3-tetradecene (C14H28),
- 1-pentadecene (C15H30),
- 3,7-dimethylnonane (C11H24),
- nonanal (C9H18O), and
- 1-propanol (C3H8O), in a sample of exhaled breath from said subject.
Dependencies are inferred from the claim text.