Systems, Devices, Components and Methods for Detecting the Locations of Sources of Cardiac Rhythm Disorders in a Patient's Heart

A system configured to detect at least one location of at least one source of at least one cardiac rhythm disorder in a patient's heart, the system comprising:

• (a) at least one computing device;
• (b) at least one data acquisition device operably connected to the at least one computing device or configured to provide as outputs therefrom at least one of intracardiac electrophysiological EP mapping signals (EP mapping signals) and body surface electrogram signals;
• (c) a display or monitor operably connected to the at least one computing device and configured to visually display to the user one or more maps generated by the at least one computing device;
• wherein the computing device comprises at least one non-transitory computer readable medium configured to store instructions executable by at least one processor to determine the at least one location of the at least one source of the at least one cardiac rhythm disorder in the patient's heart, the computing device being configured to:
• (i) receive at least one of the intracardiac EP mapping signals and the body surface electrogram signals from at least one of a plurality of intracardiac electrodes located inside the patient's heart and a plurality of body surface electrodes located on the patient's body, where amplitudes of at least one of the intracardiac EP mapping signals and the body surface electrogram signals received by the at least one computing device have been at least one of conditioned, amplified, normalized, filtered, and adjusted by the data acquisition device before being provided to the computing device;
• (ii) assign or relate positional data corresponding to predetermined positions of at least one of the intracardiac electrodes in the patient's heart and the body surface electrodes on the patient's body to their respective corresponding:
• (1) intracardiac EP mapping signals and intracardiac electrodes, and (2) body surface electrogram signals and body surface electrodes;
• (iii) generate at least one spatial map of at least one of the intracardiac electrode positions and the body surface electrode positions;
• (iv) for each or selected discrete times over which at least one of the intracardiac EP mapping signals and the body surface electrogram signals are being processed, process at least one of the amplitude-adjusted intracardiac EP mapping signals and the amplitude-adjusted body surface electrogram signals to generate a plurality of electrogram surfaces or data grids, each such surface or data grid corresponding at least partially to the at least one spatial map, at least one surface or data grid being generated for each such time, and (v) using at least one of electrographic flow (EGF), video tracking analysis, motion capture analysis, motion estimation analysis, data association and segmentation tracking analysis, particle tracking analysis, and single-particle tracking analysis methods to process the plurality of electrogram surfaces or data grids through time to generate at least one map corresponding at least partially to the spatial map, the at least one map being configured to reveal the at least one location of the at least one source of the at least one cardiac rhythm disorder, the at least one map being shown to the user on the display or monitor.