Treatment and prevention of seed allergies
AssigneesTel HaShomer Medical Research Infrastructure and Services Ltd., The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organizatio
InventorsMona KIDON, Ran HOVAV
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Abstract
A composition of matter comprising an extract of a plurality of seeds of an edible plant of interest is disclosed. Use of the composition and methods of generating same are also disclosed.
Claims40
A composition of matter comprising an extract of a plurality of non-mature seeds of an edible plant of interest, wherein said seeds are at a developmental stage such that the extract has a decreased allergenicity following processing compared to the allergenicity of an extract of fully mature seeds of said plant following said processing in at least 25% of subjects characterized as being allergic to fully mature seeds of said plant, wherein said developmental stage is such that the seed comprises at least 50% of an amount of at least one allergenic protein which is comprised in said fully mature seed, wherein said composition of matter is essentially devoid of fully mature seeds of said edible plant, wherein said allergenicity is assayed by measuring the allergic reaction in said subject following topical application.
A composition of matter comprising an extract of a plurality of seeds of an edible plant of interest, wherein said seeds are at a developmental stage which corresponds to an increased tendency of at least one allergenic protein of said seeds to undergo denaturation following processing compared to the tendency of said at least one storage protein of a fully mature seed to undergo denaturation following said processing, wherein said at least one allergenic protein of said seed is denatured in the extract, wherein said composition of matter is essentially devoid of non-denatured allergenic proteins of fully mature seeds.
(canceled)
7-8. (canceled)
14-18. (canceled)
A method of generating a composition of matter comprising an extract of seeds of an edible plant, the method comprising:
- (a) selecting seeds of said edible plant which are at a developmental stage which correspond to a reduced allergenicity of at least one allergenic protein of said seeds following processing compared to the allergenicity of said at least one allergenic protein of fully mature seeds of said edible plant following said processing in at least 25% of subjects characterized as being allergic to fully mature seeds of said plant, wherein said developmental stage is such that the seed comprises at least 50% of an amount of at least one allergenic protein which is comprised in said fully mature seed;
- (b) isolating the seeds selected according to step (a) so as to generate a collection of seeds which is devoid of mature seeds of said edible plant, and
- (c) drying said collection of seeds, thereby generating the composition.
A method of generating a composition of matter comprising an extract of seeds of an edible plant, the method comprising:
- (a) selecting seeds of said plant which are at a developmental stage which correspond to an increased tendency of at least one allergenic protein of said seeds to undergo denaturation following processing compared to the tendency of said at least one allergenic protein of a fully mature seed to undergo denaturation following said processing;
- (b) isolating the seeds selected according to step (a) so as to generate a collection of seeds which is devoid of mature seeds of said edible plant,
- (c) processing said collection of seeds for a length of time that denatures said at least one allergenic protein, thereby generating the composition.
(canceled)
Dependencies are inferred from the claim text.