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US 2020/0341015 A1Published application
Prenylation assay
AssigneesNightstaRx Ltd., Oxford University Innovation Limited
InventorsRobert Maclaren, Maria Ines Moreira Patricio, Gregory S. Robinson
Life of this patent
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Abstract
A method for determining the activity of Rab escort protein 1 (REP1) comprising the steps: (a) providing a sample comprising REP1; (b) contacting the sample of step (a) with Rab6a, Rab geranylgeranyltransferase (Rab GGTase) and a lipid donor substrate; and (c) detecting the lipidated Rab6a product.
Claims31
A method for determining an activity of Rab escort protein 1 (REP1) comprising the steps:
- (a) contacting a REP1 protein with a Rab6a protein, a Rab geranylgeranyltransferase (Rab GGTase) and a lipid donor substrate to produce a lipidated Rab6a;
- and
- (b) detecting the lipidated Rab6a.
A use of a Rab6a protein for determining an activity of a Rab escort protein 1 (REP1) protein.
Dependencies are inferred from the claim text.