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US 2020/0330614 A1Published application
Imaging Neurotransmitters In Vivo Using Functionalized Carbon Nanotubes
AssigneeThe Regents of the University of California
InventorsMarkita P. Del Carpio Landry, Linda A. Wilbrecht, Jackson Travis Del Bonis-O'Donnell, Abraham G. Beyene
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Abstract
Imaging based detection of changes in extracellular neurotransmitter concentration in living tissue is achieved using novel nanotube-based sensors. The sensors are functionalized, neurocompatible single-walled carbon nanotubes (SWNT) comprising an adsorbed neurotransmitter analyte selective polynucleotide.
Claims22
1-20. (canceled)
A method of imaging in mammalian brain tissue comprising:
- detecting changes in extracellular concentration of a neurotransmitter with a sensor located in live brain tissue in a brain slice or live mammal, the sensor comprising a functionalized, neurocompatible single-walled carbon nanotube (SWNT) comprising an adsorbed neurotransmitter-selective polynucleotide covalently bound to a neurocompatible polyethyleneglycol (PEG), wherein the polynucleotide is ssDNA or ssRNA, and the polynucleotide is a polyGT that is (GT)n, wherein n is an integer 4-30, wherein the sensor exhibits detectably greater fluorescence in the presence of the neurotransmitter than in the absence thereof.
(canceled)
Dependencies are inferred from the claim text.