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US 2020/0330612 A1Published application
Molecular probes for detection and imaging of pancreatic cancer
AssigneePortland State University
InventorsRobert M Strongin, Martha Sibrian-Vazquez, Lei Wang, Jorge O. Escobedo Cordova, Mark A. Lowry
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Abstract
Molecular probes for detecting and imaging pancreatic cancer are disclosed. The probes are modified benzoxanthene fluorophores, which are selectively taken up by pancreatic cancer cells, such as pancreatic ductal adenocarcinoma cells. Embodiments of the disclosed probes are useful for pancreatic cancer detection, therapeutic monitoring, and/or image-guided surgery.
Claims22
A probe having a chemical structure according to general formula I, or a tautomer thereof:
- where X1 is O, S, or N(H);
- R1 is —OH, —NH2, or —ORa wherein Ra is lower alkyl;
- R2-R7 independently are H, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen;
- R8-R11 independently are H, alkyl, acyl, carboxyl, nitro, amino, substituted amino, or —SO3H;
- and
- R12 is H or lower alkyl.
3 more elements
(canceled)
(canceled)
Dependencies are inferred from the claim text.