US 2020/0325110 A1Published application

Synthetic methods

AssigneeGlaxosmithkline Intellectual Property (No.2) Limited

InventorsGregg Barcan, Jiasheng Guo, Christopher W. Morgan, Gheorghe D. Roiban, Peter W. Sutton

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Abstract

Methods for the preparation of the following compound are disclosed. The compound can be incorporated into pharmaceutical formulations, including tablets and such tablets can be used for treating cholestatic liver diseases.

Claims12

Dependent claims

A method for synthesis of the compound

comprising the step of preparation of intermediate A, (R)-2-butyl-2-ethyloxirane using an epoxide hydrolase.

Dependencies are inferred from the claim text.

Facts

Application: 16/305,439Filed 27 Jun 2017
Priority: 27 Jun 2016
Published: 15 Oct 2020
Term ends: Not estimatedThe source records don’t support an estimate.

Classification15 codes

C07D 281/10
Condensed with carbocyclic rings or ring systems: condensed with one six-membered ring
A61K 9/0053
Galenical forms characterised by the site of application: mouth and digestive tract, i.e. intraoral and peroral administration
A61K 9/2054
Polysaccharides, e.g. alginate, gums; Cyclodextrin: cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
A61K 31/554
Having seven-membered rings, e.g. azelastine, pentylenetetrazole: having at least one nitrogen and one sulfur as ring hetero atoms, e.g.…

Family

Application62/355,016Us provisional application · filed 27 Jun 2016
Application62/411,776Us provisional application · filed 24 Oct 2016
US 11,186,558 B2Related patent
US 2020/0325110 A1This patent

From the US filing history. Foreign family members aren’t listed.

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