Adenovirus and uses thereof
AssigneeJanssen Vaccines & Prevention B.V.
InventorsTaco Gilles UIL, Soumitra ROY, Selina KHAN, Jerôme H.H.V. CUSTERS
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Abstract
Provided herein are adenoviral nucleic acid sequences and adenoviral vectors comprising said nucleic acid sequences. The provided adenoviral vectors can be used to induce a protective immune response in a subject.
Claims27
An isolated nucleic acid sequence encoding a fiber polypeptide with at least 98% identity to amino acids 6-375 of SEQ ID NO:
- 2.
An isolated nucleic acid sequence encoding a hexon polypeptide comprising a hexon hypervariable regions-encompassing polypeptide comprising an amino acid sequence selected from SEQ ID NO:5 or SEQ ID NO:6.
An adenoviral vector comprising:
- (a) at least one transgene;
- and
- (b) a nucleic acid sequence encoding a fiber polypeptide, wherein the fiber polypeptide comprises an amino acid sequence with at least 98% identity to amino acids 6-375 of SEQ ID NO:2.
Dependencies are inferred from the claim text.