Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
AssigneeStealth BioTherapeutics Inc.
InventorD. Travis Wilson
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Abstract
Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of a therapeutic biological molecule, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to a therapeutic biological molecule and uses of the same. In some embodiments, the aromatic-cationic peptide comprises 2′,6′-dimethyl-Tyr-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2, or D-Arg-2′,6′-Dmt-Lys-Phe-NH2.
Claims8
-31. (canceled)
A method for delivering an aromatic-cationic peptide and/or a therapeutic biological molecule to a cell, the method comprising contacting the cell with a peptide conjugate, wherein the peptide conjugate comprises the therapeutic biological molecule conjugated to an aromatic-cationic peptide, wherein the aromatic-cationic peptide is selected from the group consisting of:
- 2′,6′-dimethyl-Tyr-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2, D-Arg-2′,6′-Dmt-Lys-Phe-NH2, and a peptide of Table A, Table 5, Table 6 or Table 7;
- and wherein the therapeutic biological molecule is a compound described in Section I.
-58. (canceled)
Dependencies are inferred from the claim text.