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AssigneesIndiana University Research and Technology Corporation, Yissum Research Development Company of the Hebrew University of Jerusalem
InventorsDomb Abraham Jacob, Michael Kubek
Estimating the term…
Compositions comprising nanoparticles are described herein. At least a portion of the nanoparticles comprises a lipid and/or polymer which is water-insoluble, and an agent incorporated in the lipid and/or polymer. The nanoparticles are optionally associated with a surface of water-soluble particles which comprise a water-soluble compound. The polymer is optionally a polyanhydride. Further described herein are processes for preparing such compositions, comprising contacting a solution comprising the lipid and/or polymer dissolved in a non-aqueous solvent with an anti-solvent (in which the lipid and/or polymer and agent are insoluble) which is miscible with the non-aqueous solvent. Further described herein are uses of the compositions for nasal administration, and devices configured for nasal administration of the composition upon atomization.
A composition comprising a plurality of nanoparticles, at least a portion of said nanoparticles are nanoparticles comprising a lipid and/or polymer, said lipid and/or polymer being water-insoluble, and an agent incorporated in said lipid and/or polymer, wherein said nanoparticles are associated with a surface of water-soluble particles which comprise at least one water-soluble compound.
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A process for preparing a composition comprising a plurality of nanoparticles, at least a portion of said nanoparticles are nanoparticles comprising a lipid and/or polymer, said lipid and/or polymer being water-insoluble, and an agent incorporated in said lipid and/or polymer, wherein said nanoparticles are associated with a surface of water-soluble particles which comprise at least one water-soluble compound the process comprising contacting a solution comprising said lipid and/or polymer dissolved in a nonaqueous solvent with a dispersion of said water-soluble particles in an anti-solvent, wherein said anti-solvent is miscible with said non-aqueous solvent and wherein said lipid and/or polymer, said agent and said water-soluble compound are each insoluble in said anti-solvent.
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Dependencies are inferred from the claim text.