Drug delivery device, method of manufacture, and method of use

A wearable drug delivery device comprising:

• a housing;
• a container disposed in the housing, the container including a barrel and a plunger seal moveable through the barrel;
• a drug disposed in the barrel, the drug comprising at least one of a Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) specific antibody, a granulocyte colony-stimulating factor (G-CSF), a sclerostin antibody, or a calcitonin gene-related peptide (CGRP) antibody;
• a cannula initially having an internal passage and configured to be operably connected in fluid communication with the container to deliver the drug to a patient during use of the wearable drug delivery device;
• an introducer needle initially disposed in the cannula and configured for introducing the cannula into the patient's skin;
• a drive mechanism disposed in the housing and including
• a piston moveable relative to the housing and configured to impart movement to the plunger seal,
• a piston biasing member initially retained in a piston biasing member energized state, the piston biasing member being configured to move the piston as the piston biasing member de-energizes,
• a winch configured to rotate relative to the housing, and
• a tether including a first end connected to the piston and a second end wound around the winch, the tether initially retaining the piston biasing member in the piston biasing member energized state, wherein rotation of the winch unwinds the tether to allow the piston biasing member to de-energize;
• and
• an insertion mechanism including
• a rotational biasing member initially retained in a rotational biasing member energized state, the rotational biasing member being configured to rotate relative to the housing as the rotational biasing member de-energizes, and
• a hub operably connecting the introducer needle and cannula to the rotational biasing member, the hub being configured to translate the introducer needle and cannula into the patient's skin as the rotational biasing member de-energizes.