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US 2020/0299653 A1Published application
Cyclic GMP-Chelating Peptides for Subcellular Targetting
AssigneesSorbonne Universite, Centre National De La Recherche Scientifique, Institut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsXavier Nicol, Oriol Ros Torres
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Abstract
The disclosure pertains to the field of molecular means capable of binding to, and preferably of chelating, cGMP, appropriate for use in vitro or in vivo and preferably capable of targeting specific cellular compartments. The polypeptides of the disclosure comprise a chimeric construction derived from the N terminus part of PKG-Iα and PKG-Iβ, and the two cGMP binding sites of the wild type PKG.
Claims20
A polypeptide comprising:
- a chimeric peptide derived from the sequence SEQ ID NO:
- 1 and from the sequence SEQ ID NO:
- 2;
- a cGMP binding domain comprising or consisting of the sequence SEQ ID NO:
- 6;
- and,
- wherein said polypeptide is devoid of any catalytic domain, and its functional variants.
4 more elements
Dependencies are inferred from the claim text.