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US 2020/0299394 A1Published application
Antibodies against human and canine il-13ra2
AssigneeWake Forest University Health Sciences
InventorsWaldemar Debinski, Denise Mazess Herpai
Life of this patent
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Abstract
Provided herein are monoclonal antibodies that specifically bind IL-13RA2 with cross-reactivity in humans and canines. Also provided are methods of use of the antibodies in the treatment and monitoring of cancers.
Claims18
A method of detecting a cancer in a subject in need thereof, said method comprising:
- administering to said subject an antibody that specifically binds an epitope within amino acids spanning the extracellular portion of human IL-13RA2, wherein said antibody is coupled to a detectable group, in an amount effective to detect said antibody, wherein said epitope is within amino acids spanning the extracellular portion of human IL-13RA2 that have at least 90% identity with the corresponding canine sequence of IL-13RA2;
- and
- detecting said detectable group, to thereby detect the cancer in the subject.
Dependencies are inferred from the claim text.